Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 13,000 |
5 mg | 在庫あり | ¥ 28,000 |
10 mg | 在庫あり | ¥ 45,500 |
25 mg | 在庫あり | ¥ 104,500 |
50 mg | お問い合わせ | ¥ 154,500 |
100 mg | お問い合わせ | ¥ 219,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 30,500 |
説明 | RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM). |
ターゲット&IC50 | SHP2:0.583 nM |
In vitro | RMC-4550 stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide but lacks activity against the free catalytic domain of SHP2 [1]. |
In vivo | RMC-4550 has moderate to high bioavailability and has a half-life amenable for once daily oral administration. In the EGFR-driven KYSE-520 human esophageal cancer xenograft model, RMC-4550 has a dose dependent efficacy consistent with target modulation, assessed by phospho-ERK inhibition in tumors. RMC-4550 is well tolerated at doses that achieved maximal and sustained efficacy in this model[2]. |
分子量 | 437.36 |
分子式 | C21H26Cl2N4O2 |
CAS No. | 2172651-73-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (571.61 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RMC-4550 2172651-73-7 Metabolism Phosphatase Inhibitor inhibit RMC4550 RMC 4550 inhibitor