Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RWJ-51204 is a selective adenosine A2A receptor antagonist and a partial agonist of GABA(A) receptor (IC50: 0.2-2 nM). It has neuroprotective and movement-improving effects and can be used in research related to Parkinson's disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,500 |
5 mg | 在庫あり | ¥ 190,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 365,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
500 mg | 在庫あり | ¥ 1,124,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 169,500 |
説明 | RWJ-51204 is a selective adenosine A2A receptor antagonist and a partial agonist of GABA(A) receptor (IC50: 0.2-2 nM). It has neuroprotective and movement-improving effects and can be used in research related to Parkinson's disease. |
ターゲット&IC50 | GABAA:0.2-2 nM(ki) |
In vitro | RWJ-51204 binds to receptors with Ki ranging from 0.2 to 0.6 nM in the cerebral cortex, cerebellum, or medulla-spinal cord.[1] |
In vivo | RWJ-51204 is effective in the conflict test in monkeys (ED50 of approximately 0.5 mg/kg p.o.). RWJ-51204 is orally active in anxiolytic efficacy tests. RWJ-51204 effectively impairs rotarod performance in rats (ED50 = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance. [1] |
分子量 | 399.39 |
分子式 | C21H19F2N3O3 |
CAS No. | 205701-85-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.99 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RWJ-51204 205701-85-5 Membrane transporter/Ion channel Neuroscience GABA Receptor RWJ51204 RWJ 51204 Inhibitor inhibitor inhibit