Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
説明 | Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II. |
In vitro | Rebeccamycin produced by the actinomycete Saccharotrix aerocolonigenes. It has activity against several human tumor cell lines, including lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma. Rebeccamycin displays antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis [1][3]. |
In vivo | Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma and L1210 leukemia[2]. |
分子量 | 570.38 |
分子式 | C27H21Cl2N3O7 |
CAS No. | 93908-02-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Rebeccamycin 93908-02-2 DNA Damage/DNA Repair Topoisomerase Inhibitor inhibitor inhibit