Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.
説明 | Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury. |
ターゲット&IC50 | OCT1:2.2 μM |
In vitro | Retrorsine inhibited the OCT1-mediated 1-methyl-4-phenylpyridinium (MPP(+)) uptake in MDCK-hOCT1 cells with the IC50 of 2.25±0.30μM[1]. Retrorsine (60 μM, 120 μM , 240 μM; 24 h) significantly reduced HSEC-CYP3A4 cell viability and GSH levels and increases the formation of pyrrole-protein adducts[2]. |
In vivo | In male Wistar rats, Retrorsine (30 mg/kg; i.p.; twice) impaired liver regeneration in the PBL model not only by an S or G2/M phase block but also by a block located before the G1/S transition of the cell cycle[3]. |
植物由来 |
分子量 | 351.39 |
分子式 | C18H25NO6 |
CAS No. | 480-54-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (270.35 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Retrorsine 480-54-6 Membrane transporter/Ion channel Metabolism OCT P450 pyrrolizidine inhibit hepatotoxic hepatocellular Inhibitor injury alkaloid inhibitor