hepatotoxic | TargetMol

カタログ番号	製品名	別名	ターゲット
T0712	Suloctidil		ATPase , Platelet aggregation
	Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.		ATPase , Platelet aggregation
T32579	Lasiocarpine HCl	Lasiocarpine hydrochloride
	Lasiocarpine HCl is a hepatotoxic and carcinogenic food contaminant.
T69106	Avarol
	Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheim...
T32982	Luteoskyrin	Flavomycelin
	Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.
T61515	5-HT7 receptor ligand 1
	5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions w...
T40688	Fulvine
	Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo.
T63337	CYP2C19-IN-1
	CYP2C19-IN-1 is a potent, non-genotoxic, non-hepatotoxic inhibitor of CYP2C19. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) (Ki: 6.16 μM) and can be used to study Zika virus (ZIKV) infection.
T35777	Nodularin
	The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatot...

Compounds

Suloctidil

T0712

Synonym:

Target: ATPase, Platelet aggregation

Lasiocarpine HCl

T32579

Synonym: Lasiocarpine hydrochloride

Synonym: Flavomycelin

Target:

5-HT7 receptor ligand 1

カタログ番号	製品名	別名	ターゲット
TN2147	Retrorsine		P450 , OCT
	Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells. Retrorsine can be used for the research of hepatocellular injury.		P450 , OCT
T3409	Plantamajoside	Y0160,C10485	Others
	Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.		Others
TQ0192	Senecionine	Aureine,Senecionan-11,16-dione, 12-hydroxy-,Senecionin	Others
	Senecionine (Senecionin) is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.		Others
T2S1158	4,5-Dicaffeoylquinic acid	3,4-Dicaffeoylquinic acid,Isochlorogenic acid C	Others , HBV , Endogenous Metabolite
	1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.		Others , HBV , Endogenous Metabolite
T4S1718	Punicalin		HBV , HIV Protease
	Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).		HBV , HIV Protease
T3879	Silychristin	Silicristin	Lipoxygenase
	Silychristin (Silicristin) is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.		Lipoxygenase
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
TN1078	Seneciphylline		P450 , GST
	Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat...		P450 , GST
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
T40856	7-Acetylintermedine
	7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid.
T25724	Ligularine
	Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine.
TL0011	Adonifoline		Others
	Adonifoline is a hepatotoxic pyrrolizidine alkaloid.		Others
TN3835	Desacetyldoronine		Others
	Desacetyldoronine is a hepatotoxic pyrrolizidine alkaloid.		Others
T81795	Microcystin-WR
	Microcystin-WR, a hepatotoxic metabolite derived from cyanobacteria, has been demonstrated to induce hepatotoxicity in mice [1].
TN3180	6-O-(3'',4''-Dimethoxycinnamoyl)catalpol		Others
	6-O-(3'',4''-Dimethoxycinnamoyl)catalpol has anti-hepatotoxic activity.		Others
TN4346	Jaconine		Others
	Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.		Others
T40627	Trichodesmine
	Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo.
TN3913	Echimidine		Antifection
	Echimidine, a major hepatotoxic dehydropyrrolizidine alkaloid produced by E. plantagineum, in the honey (780 ng/g) and in the subsequent mead samples (236-540 ng/mL). Echimidine-N-Oxide has antifungal activity.		Antifection