store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylation of S473pAKT.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 75,500 | |||
25 mg | 在庫あり | ¥ 152,000 | |||
50 mg | 在庫あり | ¥ 228,500 | |||
100 mg | 在庫あり | ¥ 385,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor.Rheb inhibitor NR1 inhibits the phosphorylation of T389pS6K1 and promotes the phosphorylation of S473pAKT. |
In vivo | In male C57BL/6 mice aged 6-7 weeks (fasted for 16 hours), administration of the Rheb inhibitor NR1 (30 mg/kg; intraperitoneal injection; single dose) resulted in significantly reduced mTORC1 activity in both kidney and skeletal muscle. Additionally, a clear band shift for T37/464E-BP1 was observed in skeletal muscle[1]. |
分子量 | 578.3 |
分子式 | C25H19BrCl2N2O3S |
CAS No. | 2216763-38-9 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (34.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rheb inhibitor NR1 2216763-38-9 PI3K/Akt/mTOR signaling mTOR Rheb inhibitor NR-1 Inhibitor inhibitor inhibit