Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 27,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 99,500 | |||
50 mg | 在庫あり | ¥ 146,500 | |||
100 mg | 在庫あり | ¥ 205,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 36,500 |
説明 | BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively. |
ターゲット&IC50 | PI3Kγ:38 nM, PI3Kα:4 nM, PI3Kβ:63 nM |
In vitro | Growth inhibition experiment showed that BGT226 had antitumor activity. BGT226 significantly inhibited cell growth with IC50 < 20 nM. BGT226 also induced cancer cell apoptosis at nanomolar concentration, IC50 ≤ 25 nM[1][2][3]. |
In vivo | BGT226 significantly delayed tumor growth on the transplanted tumor animal model. This effect was dose-dependent, accompanied by inhibition of p-p70 S6 kinase cytoplasmic expression and autophagy body formation[2]. |
別名 | BGT226 free base, NVP-BGT226 |
分子量 | 534.53 |
分子式 | C28H25F3N6O2 |
CAS No. | 915020-55-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (121.6 mM)
You can also refer to dose conversion for different animals. 詳細
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BGT226 915020-55-2 Autophagy PI3K/Akt/mTOR signaling PI3K mTOR inhibit Mammalian target of Rapamycin NVP-BGT 226 BGT-226 NVP-BGT-226 BGT 226 BGT226 free base Inhibitor Phosphoinositide 3-kinase NVP-BGT226 inhibitor