store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 64,000 |
5 mg | 在庫あり | ¥ 159,000 |
10 mg | 在庫あり | ¥ 227,000 |
25 mg | 在庫あり | ¥ 335,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia. |
In vivo | In a dose-dependent manner, Risarestat inhibits the accumulation of dulcitol, with the exception of the 1.0% solution, which exhibits activity comparable to the 0.25% solution[1]. Following instillation, Risarestat peaks in the corneal epithelium, stroma, endothelium, and aqueous humor within 30 minutes, gradually diminishing time-dependently over 24 hours. Risarestat remains detectable in the lens for up to 24 hours, with a peak concentration observed at 2 hours after instillation[2]. In the group treated with Risarestat, the anterior surface area of superficial cells significantly decreases from a mean value of 881 to 728 microns^2. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm^2[3]. Animals treated with Risarestat show a significant increase in the mean blink response compared to untreated galactose-fed rats, and the response does not differ significantly from controls toward the completion of the 7-month study. However, animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks[3]. |
別名 | CT 112 |
分子量 | 323.41 |
分子式 | C16H21NO4S |
CAS No. | 79714-31-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (154.60 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Risarestat 79714-31-1 Endocrinology/Hormones Metabolism Reductase CT 112 CT-112 CT112 Inhibitor inhibitor inhibit