Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).
説明 | Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM). |
ターゲット&IC50 | Aldose reductase:320 nM |
In vitro | In the murine oral administration test, the LD50 of Isoliquiritigenin is greater than 6 g/kg. |
In vivo | Isoliquiritigenin induces cell cycle arrest and inhibits cell growth in DU145 and LNCaP cell lines. In human gastric cancer MGC-803 cells, isoliquiritigenin triggers apoptosis by elevating intracellular free calcium ion concentrations and decreasing mitochondrial membrane potential (Δψ(m)). |
植物由来 |
別名 | ISL, Isoliquiritigen, GU17 |
分子量 | 256.25 |
分子式 | C15H12O4 |
CAS No. | 961-29-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5% DMSO+95% Saline: 2.55 mg/mL (9.95 mM, precipitation)
DMSO: 60 mg/mL (234.15 mM)
Ethanol: 22 mg/mL(85.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Isoliquiritigenin 961-29-5 Apoptosis Autophagy Endocrinology/Hormones Metabolism Microbiology/Virology Influenza Virus Reductase SJ 000286237 Inhibitor SJ-000286237 ISL Aldose Reductase Isoliquiritigen inhibit SJ000286237 GU-17 GU 17 GU17 inhibitor