Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 在庫あり | ¥ 22,500 |
10 mg | 在庫あり | ¥ 36,000 |
25 mg | 在庫あり | ¥ 73,500 |
50 mg | 在庫あり | ¥ 128,000 |
100 mg | 在庫あり | ¥ 149,000 |
説明 | Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro. |
ターゲット&IC50 | CBF:1.1 μM |
別名 | CBFβ-Runx1 inhibitor II, Ro 5-3335 |
分子量 | 259.69 |
分子式 | C13H10ClN3O |
CAS No. | 30195-30-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (231.04 mM)
You can also refer to dose conversion for different animals. 詳細
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Ro5-3335 30195-30-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis CBFb-Runx1 inhibitor II Ro53335 CBFβ CBFβ-Runx1 inhibitor II inhibit Ro 5-3335 binding CBFbeta-Runx1 inhibitor II Ro-5-3335 core RUNX1 RUNX1-CBFB factor CBF interaction leukemia Inhibitor Ro5 3335 inhibitor