Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 26,000 |
5 mg | お問い合わせ | ¥ 66,500 |
10 mg | お問い合わせ | ¥ 91,000 |
25 mg | お問い合わせ | ¥ 149,000 |
50 mg | お問い合わせ | ¥ 209,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 73,000 |
説明 | Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects. |
In vitro | In MOLT-4 but not Jurkat cells, Rosiptor (0.1-10 μM, 30 minutes) inhibits Akt activation [1]. |
In vivo | Rosiptor (10 mg/kg, p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability [1]. Rosiptor (3-30 mg/kg, p.o., daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity [2]. |
細胞研究 | Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation) [1]. Concentration: 0.1, 1, 10 μM. Incubation Time: 30 minutes |
動物実験 | Animal Model: 6-8 weeks old male CD-1 mice[1]. Dosage: 3, 10, 30 mg/kg. Administration: p.o., daily for 3 days |
別名 | AQX-1125 |
分子量 | 321.5 |
分子式 | C20H35NO2 |
CAS No. | 782487-28-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 145 mg/mL (451 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Rosiptor 782487-28-9 Metabolism Phosphatase AQX1125 AQX-1125 Inhibitor AQX 1125 inhibit inhibitor