Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 104,500 | |||
25 mg | 在庫あり | ¥ 171,500 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 85,000 |
説明 | Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections. |
In vitro | In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1]. |
In vivo | PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2]. |
別名 | AG-7088, AG7088, Rupintrivirvr |
分子量 | 598.66 |
分子式 | C31H39FN4O7 |
CAS No. | 223537-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (50.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rupintrivir 223537-30-2 Immunology/Inflammation Microbiology/Virology Virus Protease Antiviral AG-7088 AG7088 Rupintrivirvr AG 7088 Inhibitor inhibitor inhibit