Powder: -20°C for 3 years | In solvent: -80°C for 1 year
alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 9,500 | |||
25 mg | 在庫あり | ¥ 21,000 | |||
50 mg | 在庫あり | ¥ 38,000 | |||
100 mg | 在庫あり | ¥ 72,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree. |
ターゲット&IC50 | IDH1 (mutant, R132H):2.85 μM(ki) |
In vitro | Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells[1]. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP)[2]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin[3]. |
In vivo | Alpha-mangostin mitigates the risk of liver fibrosis by diminishing p53 expression relative to TAA_DMSO treatment. Moreover, following α-mangostin administration, serum concentrations of liver enzymes AST and ALT are reduced in comparison to treatment with DMSO alone[4]. |
細胞研究 | IDH1+/+ and IDH1<sup+/R132H MCF10A cells are grown in DMEM/F-12 media, supplemented with 5% horse serum, 20 ng/mL EGF, 0.5 μg/mL hydrocortisone, 10 μg/mL insulin. IDH1+/+ and IDH1<sup+/R132H MCF10A cells are seeded in 6 well plates. After an exposure to 5 μM alpha-mangostin. cells are collected after indicated times and the viable cell number is calculated, using hemacytometer counting[1]. |
植物由来 |
別名 | α-Mangostin, Mangostin |
分子量 | 410.46 |
分子式 | C24H26O6 |
CAS No. | 6147-11-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (109.63 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
alpha-Mangostin 6147-11-1 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb Antifungal Antibacterial Reactive Oxygen Species Virus Protease Dehydrogenase Fungal inhibit Inhibitor alpha Mangostin α-Mangostin alphaMangostin Bacterial Mangostin a-Mangostin inhibitor