Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
説明 | S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM). |
ターゲット&IC50 | BCL2:1.3 nM (ki), BCL2:3.9 nM (kd) |
In vitro | S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1]. |
In vivo | S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor. S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4 [1]. |
別名 | BLC201 |
分子量 | 710.82 |
分子式 | C43H42N4O6 |
CAS No. | 1448584-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44 mg/mL (61.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
S55746 1448584-12-0 Apoptosis BCL inhibit BLC201 S-55746 BCL-201 Inhibitor S 55746 Bcl-2 Family BCL 201 BLC-201 BCL201 BLC 201 inhibitor