Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.
説明 | SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. |
ターゲット&IC50 | NK3 (human):13 nM (Ki), NK2 (human):1220 nM (Ki) |
In vitro | SB 218795 (3-30 nM) antagonizes the contractile responses senktide-induced in a surmountable and concentration-dependent manner[1]. |
In vivo | In rabbits, SB 218795 (0.25-1 mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%[1]. |
分子量 | 396.44 |
分子式 | C25H20N2O3 |
CAS No. | 174635-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 5 mM
DMSO: 60 mg/mL (151.35 mM)
You can also refer to dose conversion for different animals. 詳細
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SB 218795 174635-53-1 GPCR/G Protein Neuroscience Neurokinin receptor constriction Neurokinin Receptor Inhibitor neurokinin-3 NK receptor pupillary SB218795 inhibit Tachykinin receptor SB-218795 NK-3 inhibitor