Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
説明 | SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects. |
In vitro | In a time- and dose-dependent manner, SP-8356 (5-10 μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10 μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP [1]. |
In vivo | In a xenograft mouse model, SP-8356 (10mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth [1]. SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability [2]. |
分子量 | 300.35 |
分子式 | C18H20O4 |
CAS No. | 1454885-45-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (199.77 mM)
You can also refer to dose conversion for different animals. 詳細
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SP-8356 1454885-45-0 Autophagy SP8356 SP 8356 Inhibitor inhibitor inhibit