Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 21,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 82,000 | |||
100 mg | 在庫あり | ¥ 107,500 | |||
200 mg | 在庫あり | ¥ 158,000 |
説明 | MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively). |
ターゲット&IC50 | ULK2:1.1 nM, ULK1:2.9 nM |
In vitro | MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells.?MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm).?Autophagy-inhibiting capacity of the compounds is specifically through ULK1.?ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation[1] |
分子量 | 507.499 |
分子式 | C25H36Cl2N6O |
CAS No. | 2080306-21-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 33.33 mg/mL (65.67 mM), Sonication is recommended.
DMSO: 2 mg/mL (3.94 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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