Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約6-8 週間 | ¥ 68,500 |
25 mg | 約6-8 週間 | ¥ 226,500 |
50 mg | 約6-8 週間 | ¥ 312,500 |
100 mg | 約6-8 週間 | ¥ 427,000 |
1 mL * 10 mM (in DMSO) | 約6-8 週間 | ¥ 84,000 |
説明 | SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively). |
ターゲット&IC50 | SRPK1:35.6 nM, SRPK2:98 nM |
In vitro | SRPK-IN-1 effectively converts VEGF from pro-angiogenic to anti-angiogenic isoform. SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) obviously decreases SR protein phosphorylation at the steady-state with or without washout [1]. |
In vivo | SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis through VEGF alternative splicing in a CNV mouse model [1]. |
分子量 | 472.53 |
分子式 | C27H21FN2O3S |
CAS No. | 2089226-94-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 110 mg/mL (232.79 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SRPKIN-1 2089226-94-6 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase SRPKIN1 SRPKIN 1 Inhibitor inhibitor inhibit