Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM.
説明 | BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the cell-cycle protein G-related BMT-124110 Formate inhibits the cell cycle protein G-associated kinase GAK with an IC50:99 nM. |
ターゲット&IC50 | AAK1:0.9 nM, GAK:99 nM, AAK1 (cells):3.2±1.4, BIKE:17 nM |
In vitro | BMT-124110 exhibits a cellular IC50 of 3.2±1.4 nM against AAK1.[1] |
In vivo | BMT-124110 (30 mM; pH 4; 110–30 nA; 3 minutes; naive male rats) is added directly onto the spinal covered by micro iontophoresis, leading to a reduction in windup-induced activity in 10/14 animals.[1] |
別名 | BMT-124110 Formate(1679371-59-5 Free base) |
分子量 | 344.41 |
分子式 | C22H20N2O2 |
CAS No. | T10572L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.15 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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BMT-124110 Formate T10572L Cell Cycle/Checkpoint Metabolism Neuroscience Stem Cells Serine/threonin kinase TGF-beta/Smad AAK1 (AP2 associated kinase 1) BMT124110 Formate 1679371-59-5 BMT 124110 Formate 1679371-59-5 Free base BMT-124110 Formate(1679371-59-5 Free base) Inhibitor inhibitor inhibit