Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
説明 | ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
ターゲット&IC50 | AC type I:2.3 μM |
In vitro | ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1]. |
In vivo | ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1]. |
分子量 | 297.95 |
分子式 | C10H4Cl4O2 |
CAS No. | 133406-29-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (167.81 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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ST034307 133406-29-8 Neuroscience Adenylyl cyclase Adenylate Cyclase Inhibitor ST-034307 inhibit ST 034307 inhibitor