Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 20,000 | |||
25 mg | 在庫あり | ¥ 42,000 | |||
50 mg | 在庫あり | ¥ 74,000 | |||
100 mg | 在庫あり | ¥ 125,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
ターゲット&IC50 | STAT5:47 μM |
In vitro | The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members. |
別名 | STAT5 Inhibitor |
分子量 | 293.28 |
分子式 | C16H11N3O3 |
CAS No. | 285986-31-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (170.49 mM)
You can also refer to dose conversion for different animals. 詳細
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STAT5-IN-1 285986-31-4 JAK/STAT signaling Stem Cells STAT STAT-5-IN-1 STAT5IN1 inhibit STAT5 IN 1 STAT5 Inhibitor Inhibitor inhibitor