Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 14,000 | |||
10 mg | 在庫あり | ¥ 23,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 88,000 | |||
100 mg | 在庫あり | ¥ 137,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis. |
In vitro | A novel HIF-1 inhibitor SYP-5 was first observed by the luciferase reporter assay. Western blots results showed SYP-5 inhibited hypoxia-induced upregulation of HIF-1. Moreover, the proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, were down-regulated by SYP-5. Furthermore, in the tube formation assay, SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro. Additionally, using Transwell and RTCA assays, we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. Detected the upstream pathways related to HIF-1 and found both PI3K/AKT and MAPK/ERK were involved in the SYP-5 mediated invasive inhibition of Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent. |
分子量 | 312.38 |
分子式 | C18H16O3S |
CAS No. | 1384268-04-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (106.70 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SYP-5 1384268-04-5 Angiogenesis Chromatin/Epigenetic Metabolism HIF HIF/HIF Prolyl-Hydroxylase Inhibitor HIFs Hypoxia-inducible factors SYP 5 inhibit SYP5 HIF-PH inhibitor