Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 17,000 | |||
25 mg | 在庫あり | ¥ 64,500 | |||
50 mg | 在庫あり | ¥ 97,000 | |||
100 mg | 在庫あり | ¥ 110,500 |
説明 | Selinexor (KPT-330) is a small molecule inhibitor of CRM1 with selective and oral activity. Selinexor blocks the cell cycle, induces apoptosis, and has antitumor activity for the treatment of multiple myeloma. |
In vitro |
METHODS: Six T-ALL cells, MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3 and DND-41, were treated with Selinexor (0-1000 µM) for 72 h. Cell growth inhibition was detected using Cell Titer Glo assay. RESULTS: Selinexor treatment inhibited T-ALL cell growth with IC50 values of 34-203 nM. [1] METHODS: Multiple myeloma cells MM1S were treated with Selinexor (100 nM) for 8 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Selinexor treatment resulted in the accumulation of p53, IκB, p21 and p27 in the nucleus of MM1S cells. [2] |
In vivo |
METHODS: To assay antitumor activity in vivo, Selinexor (20-25 mg/kg) was administered by gavage to NSG mice harboring the human T-ALL tumor MOLT-4 three times per week for thirty-six days. RESULTS: Selinexor-treated mice exhibited significant inhibition of leukemia cell growth with significant survival benefit. [1] METHODS: To assay anti-tumor activity in vivo, Selinexor (20 mg/kg) was administered by gavage three times per week for four weeks to an NSG mouse model of primary AML in patients. RESULTS: Selinexor was cytotoxic to primary AML cells transplanted into mice. [3] |
別名 | Selinexor, KPT-330 |
分子量 | 443.31 |
分子式 | C17H11F6N7O |
CAS No. | 1393477-72-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
5% DMSO+95% Saline: 4.1 mg/mL (9.25 mM, suspension)
Ethanol: 38 mg/mL (85.7 mM)
DMSO: 55 mg/mL (124.07 mM)
You can also refer to dose conversion for different animals. 詳細
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Selinexor (KPT-330) 1393477-72-9 Membrane transporter/Ion channel CRM1 KPT 330 KPT330 Selinexor Selinexor (KPT 330) KPT-330 Selinexor (KPT330) Inhibitor inhibitor inhibit