keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 77,500 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
100 mg | 在庫あり | ¥ 349,000 |
説明 | Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability. |
In vitro | When added to prostate carcinoma (PC3, DU145) or HeLa cells, shepherdin caused concentration-dependent and complete loss of cell viability[1]. |
In vivo | Shepherdin-RV (50 mg/kg, i.p., daily) nearly completely ablated tumor growth in immunocompromised mice prostating carcinoma PC3 cells. In a breast cancer xenograft model that employs MCF-7 cells adapted in vivo, injection of Shepherdin-RV resulted in exponentially growing tumors independently of estrogen supplementation, which was unaffected by saline administration. Shepherdin-RV (50 mg/kg i.p. daily) uniformly inhibited the growth of these more aggressive tumors (p = 0.01) throughout a 23-day or 11-day treatment regimen. Shepherdin treatment resulted in nearly complete loss of Akt levels in tumor cells and severely attenuated expression of survivin[1]. |
別名 | Shepherdin 79-87 acetate (861224-28-4 free base) |
分子量 | 1009.14 |
分子式 | C43H68N12O14S |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Shepherdin 79-87 acetate Apoptosis Cytoskeletal Signaling Metabolism HSP Survivin 861224-28-4 Shepherdin 79-87 acetate (861224-28-4 free base) Shepherdin 79-87 Acetate Shepherdin 79 87 acetate 861224-28-4 free base Shepherdin 7987 acetate Inhibitor inhibitor inhibit