Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 181,000 | |||
50 mg | 在庫あり | ¥ 282,500 | |||
100 mg | 在庫あり | ¥ 397,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 63,500 |
ターゲット&IC50 | Aurora A:1 nM (IC50), Aurora B:95 nM (IC50) |
In vitro | TAS-119 (30-300 nM) dose-dependently augments the growth inhibition of HeLa cells induced by three taxanes (Paclitaxel, Docetaxel, and Cabazitaxel). It specifically promotes mitotic accumulation in tumor cells over normal diploid fibroblasts. Moreover, TAS-119 amplifies the antiproliferative efficacy of Paclitaxel across a diverse array of human cancer cell lines, even those resistant to Paclitaxel.[1] |
別名 | TAS119, TAS2104, TAS 2104, TAS-2104, TAS 119 |
分子量 | 506.36 |
分子式 | C23H22Cl2FN5O3 |
CAS No. | 1453099-83-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25.32 mg/mL (50 mM)
You can also refer to dose conversion for different animals. 詳細
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TAS-119 1453099-83-6 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase TAS119 TAS2104 TAS 2104 TAS-2104 TAS 119 Inhibitor inhibitor inhibit