Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-A 2317 hydrochloride is an Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). It's selective over 60 other kinases (IC50: > 1000 nM). TC-A 2317 hydrochloride is also shown good cell permeability and antitumor activity.
説明 | TC-A 2317 hydrochloride is an Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). It's selective over 60 other kinases (IC50: > 1000 nM). TC-A 2317 hydrochloride is also shown good cell permeability and antitumor activity. |
ターゲット&IC50 | Aurora A:1.2 nM (Ki), Aurora B:101 nM (Ki) |
In vivo | In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight[1]. |
分子量 | 392.93 |
分子式 | C19H29ClN6O |
CAS No. | 1245907-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: <39mg/ml
Ethanol: <19.50mg/ml
You can also refer to dose conversion for different animals. 詳細
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TC-A 2317 hydrochloride 1245907-03-2 Cell Cycle/Checkpoint Chromatin/Epigenetic Others Aurora Kinase TC-A-2317 Hydrochloride TC-A 2317 Hydrochloride permeability oral Inhibitor selective antitumor inhibit HCT-116 TC A 2317 hydrochloride TCA 2317 hydrochloride proliferation TC-A2317 Hydrochloride TC-A 2317 inhibitor