Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK-8745 is a potent and selective Aurora A inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 8,000 | |||
10 mg | 在庫あり | ¥ 12,000 | |||
25 mg | 在庫あり | ¥ 21,000 | |||
50 mg | 在庫あり | ¥ 34,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | MK-8745 is a potent and selective Aurora A inhibitor. |
ターゲット&IC50 | Aurora A:0.6 nM |
In vivo | MK-8745 induces apoptosis in a p53-dependent manner across various cell lines in vitro. Exposure of p53 wild-type cells to MK-8745 leads to the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. This p53-dependent apoptotic effect of MK-8745 is further confirmed in HCT 116 p53 (-/-) cells transfected with wild-type p53. In non-Hodgkin's lymphoma cell lines, MK-8745 causes cell cycle arrest at the G2/M phase with the accumulation of tetraploid nuclei, followed by cell death. Treatment with MK-8745 induces p21 (waf1/cip1) and CycB1, indicating cell cycle arrest and an increased population of cells in the G2/M phase. Additionally, MK-8745 treatment leads to the rapid degradation of Aurora-A substrates (TACC3, Eg5, and TPX2) following the reduction of phospho-Aurora-A. |
分子量 | 431.91 |
分子式 | C20H19ClFN5OS |
CAS No. | 885325-71-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 1 mg/mL (2.31 mM)
DMSO: 80 mg/mL (185.2 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MK-8745 885325-71-3 Apoptosis Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase MK8745 Inhibitor inhibit MK 8745 inhibitor