Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transition from trophozoite to schizont, impairs transcription, and diminishes transmission to the mosquito vector.
説明 | TCMDC-135051 is a potent and selective PfCLK3 protein kinase inhibitor demonstrating significant antiparasiticidal activity (EC50=320 nM) while exhibiting minimal off-target toxicity. It effectively hinders the transition from trophozoite to schizont, impairs transcription, and diminishes transmission to the mosquito vector. |
In vitro | In a liver invasion and development assay, TCMDC-135051 shows potent activity against P. berghei sporozoites in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM). The kinase assays using recombinant PvCLK3 (P. vivax) and PbCLK3 (P. berghei) show that TCMDC-135051 has near-equipotent inhibition at these two orthologs, with pIC50 values of 7.47 (IC50=0.033 μM) and 7.86 (IC50=0.013 μM), respectively[1]. |
分子量 | 471.59 |
分子式 | C29H33N3O3 |
CAS No. | 2413716-15-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (477.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TCMDC-135051 2413716-15-9 Others TCMDC135051 TCMDC 135051 Inhibitor inhibitor inhibit