Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 548,500 |
50 mg | 約10-14 週間 | ¥ 888,500 |
100 mg | 約10-14 週間 | ¥ 1,430,000 |
説明 | Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations. |
In vivo | In male Sprague-Dawley rats, oral administration of rodatristat ethyl at doses of 100 or 200 mg/kg once daily for 28 days results in a dose-dependent decrease in serum, gut, and lung 5-HT levels. This treatment significantly reduces pulmonary arterial pressure as well as pulmonary vessel wall thickness and occlusion in rats with monocrotaline (MCT)-induced pulmonary hypertension[2]. |
別名 | RVT-014, KAR5585, RVT-1201 |
分子量 | 590.04 |
分子式 | C29H31ClF3N5O3 |
CAS No. | 1673571-51-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (152.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rodatristat ethyl 1673571-51-1 GPCR/G Protein Metabolism Neuroscience Hydroxylase 5-HT Receptor RVT-014 KAR-5585 KAR 5585 KAR5585 RVT-1201 Inhibitor inhibitor inhibit