Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 85,500 | |||
100 mg | 在庫あり | ¥ 128,000 |
説明 | TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity. |
ターゲット&IC50 | TLR5/flagellin complex:0.85 μM (IC50) |
In vivo | TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5. |
分子量 | 453.54 |
分子式 | C23H15N7S2 |
CAS No. | 1841460-82-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.54 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TH1020 1841460-82-9 Immunology/Inflammation Microbiology/Virology Antibacterial TLR interaction inhibit Bacterial flagellin Toll-like Receptor (TLR) TLR5 protein-protein TH-1020 TNF-α Inhibitor TH 1020 inhibitor