Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 51,000 |
5 mg | 在庫あり | ¥ 129,500 |
10 mg | 在庫あり | ¥ 186,500 |
25 mg | 在庫あり | ¥ 282,500 |
50 mg | 在庫あり | ¥ 383,500 |
100 mg | 在庫あり | ¥ 519,000 |
500 mg | 在庫あり | ¥ 1,040,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 142,000 |
説明 | TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer lasting effect than sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use. |
ターゲット&IC50 | PDE5:0.62 nM |
分子量 | 441.57 |
分子式 | C24H35N5O3 |
CAS No. | 1229018-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (51.0 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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TPN171 1229018-87-4 Metabolism PDE TPN 171 TPN-171 Inhibitor inhibitor inhibit