Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
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10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 17,500 | |||
100 mg | 在庫あり | ¥ 24,500 | |||
200 mg | 在庫あり | ¥ 37,500 | |||
500 mg | 在庫あり | ¥ 64,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). |
ターゲット&IC50 | Proton transport:3.2 μM |
In vitro | Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain. [1] |
In vivo | Tenatoprazole provides slow activation in vivo, which is predicted by its chemical activation rate in fasting rats. Tenatoprazole inhibits about 20–30% of enzyme activity even though acid secretion in fasting rats. (S)-tenatoprazole sodium salt hydrate provides a higher Cmax of 183 ng/mL, Tmax of 1.3 hours and AUC of 822 ng*h/mL in dog. [1] |
別名 | TU-199 |
分子量 | 346.4 |
分子式 | C16H18N4O3S |
CAS No. | 113712-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43 mg/mL (124.1 mM)
Ethanol: 12 mg/mL (34.6 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Tenatoprazole 113712-98-4 Membrane transporter/Ion channel Proton pump Proton Pump TU199 Inhibitor gastric ATPase Tsg101 inhibit virus oral secretion TU 199 acid TU-199 inhibitor