Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
説明 | VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM). |
ターゲット&IC50 | mGlu1:99 nM |
In vivo | VU 0469650 (10 mg/kg; I.P.; once; male Sprague-Dawley rats) shows an excellent selectivity profile and good exposure in both plasma and brain samples.[1] VU 0469650 (0.2 mg/kg; I.V.; once; male Sprague-Dawley rats) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.[1] |
別名 | VU0469650, VU 0469650, VU-0469650, VU 0469650 HCl |
分子量 | 364.48 |
分子式 | C22H28N4O |
CAS No. | 1443748-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 45.0 mg/mL (112.2 mM)
DMSO: 90.0 mg/mL (224.5 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VU 0469650 1443748-47-7 Neuroscience GluR VU0469650 VU-0469650 VU 0469650 HCl Inhibitor inhibitor inhibit