Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 14,000 | |||
25 mg | 在庫あり | ¥ 29,500 | |||
50 mg | 在庫あり | ¥ 56,500 | |||
100 mg | 在庫あり | ¥ 108,500 | |||
500 mg | 在庫あり | ¥ 226,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 15,500 |
説明 | 7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery. |
ターゲット&IC50 | Glycine B coagonist site of NMDA receptor:0.56 μM(ki), Reuptake of glutamate:(ki)0.59 μM |
In vivo | In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response[3]. |
別名 | 7-chloro-4-hydroxy-2-carboxyquinoline, 7-CKA |
分子量 | 223.61 |
分子式 | C10H6ClNO3 |
CAS No. | 18000-24-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (67.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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7-Chlorokynurenic acid 18000-24-3 Neuroscience GluR NMDAR 7-chloro-4-hydroxy-2-carboxyquinoline 7-CKA Inhibitor inhibitor inhibit