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1813

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天然化合物

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TargetMolキット

カタログ番号	製品名	別名	ターゲット
T35788	Orlistat Degradation Product (sodium salt)
	Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase.
T75026	PROTAC TYK2 degradation agent1		PROTACs
	PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].		PROTACs
T21572	Erythromycin A enol ether		Others
	Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic.		Others
T4066	FIN56		Ferroptosis
	FIN56 is a specific inducer of ferroptosis.		Ferroptosis
T8710	MSAB		Wnt/beta-catenin
	MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.		Wnt/beta-catenin
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T39598	4-Chlorocatechol		Others
	4-Chlorocatechol, a significant degradation product of 4-chloro-2-aminophenol (4C2AP), serves as a substrate for both catechol 1,2-dioxygenases and chlorocatechol dioxygenase [1] [2].		Others
T20933	Bis(p-chlorophenyl)acetic acid	Bis(p-chlorphenyl)essigsaeure,Bis(4-chlorophenyl)acetic acid,DDA (degradation product),DDA
	Bis(p-chlorophenyl)acetic acid is a standard for pesticide residue analysis.
T21773	SP-141	SP 141	Mdm2
	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.		Mdm2
T5436	MZ 1		Epigenetic Reader Domain
	MZ 1 is a BRD4 protein degrader based on PROTAC technology.		Epigenetic Reader Domain
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T8773	MID-1		Others , IGF-1R
	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet...		Others , IGF-1R
T21616	L-006235	L 006235	Cysteine Protease
	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.		Cysteine Protease
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T1818	Tenovin-6	Tenovin 6	Dehydrogenase , Sirtuin , Autophagy
	Tenovin-6 is a p53 transcriptional activity agonist.		Dehydrogenase , Sirtuin , Autophagy
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T23820	BRD32048	BRD-32048,BRD 32048	DNA/RNA Synthesis
	BRD32048 is the ETV1 transcription factor oncoprotein inhibitor.		DNA/RNA Synthesis
T12832	Amcenestrant	SAR439859	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T8480	Tenovin-6 Hydrochloride		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T6275	Obatoclax Mesylate	Obatoclax,GX15-070	BCL , Parasite , Autophagy
	Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3.		BCL , Parasite , Autophagy
T1642	Lenalidomide	CC-5013	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T9758	DCeMM3	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide	Others
	dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati...		Others
T13244	Ubiquitination-IN-1		Others
			Others
T10765	Eragidomide	CC-90009,Cereblon modulator 1	Apoptosis , Ligand for E3 Ligase , Molecular Glues
	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.		Apoptosis , Ligand for E3 Ligase , Molecular Glues
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T6763	Xevinapant	ARRY-334543,SM-406,AT406,Debio-1143	IAP
	Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, ...		IAP
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	PIK-III analogue	PI3K
	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)		PI3K
T1602	Valproic acid sodium salt	Sodium Valproate	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
	Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T6474	Divalproex Sodium	Valproate semisodium,Epival	HDAC
	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...		HDAC
T3299	Xevinapant hydrochloride	AT-406 HCl,SM-406	Apoptosis , IAP
	Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66....		Apoptosis , IAP
T15381	Gisadenafil	UK-369003	PDE
	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.		PDE
T9370	DCBP-1		Epigenetic Reader Domain , Ligand for E3 Ligase
	dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.		Epigenetic Reader Domain , Ligand for E3 Ligase
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal...
T3653	MX69		Mdm2 , E1/E2/E3 Enzyme , IAP
	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.		Mdm2 , E1/E2/E3 Enzyme , IAP
T1398	Tadalafil	Cialis,IC-351	Apoptosis , PDE
	Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGM...		Apoptosis , PDE
T14450	Azido-PEG4-hydrazide		Others
	Azido-PEG4-hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T4253	Skp2 Inhibitor C1	SKPin C1	Others , E1/E2/E3 Enzyme
	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.		Others , E1/E2/E3 Enzyme
T30663	Orange I	Orange I, sodium salt,Tertracid Orange I,α-Naphthol Orange,C.I. Acid Orange 20
	Orange I (α-Naphthol Orange) is an aromatic sulfonated p-azo dye that interferes with microbial degradation.
T20435L	Leuphasyl TFA		Opioid Receptor
	Leuphasyl TFA is an amid peptide, a δ-opioid receptor agonist, is a degradation resistant long-acting Leu-enkephalin analog used to study the signaling pathway of delta opioid receptors. Leuphasyl TFA is a potent, long-a...		Opioid Receptor
T9383	Pomalidomide-PEG2-OH	1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-	PROTACs
	Pomalidomide-PEG2-OH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.		PROTACs
T12818	S119-8		Influenza Virus
	RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting gen...		Influenza Virus
T9384	Pomalidomide-PEG3-OH	1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]-	PROTACs
	Pomalidomide-PEG3-OH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.		PROTACs
T6910	NSC59984		p53
	NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.		p53
T7440	P,p'-DDE	p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene	Androgen Receptor , Drug Metabolite
	p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT		Androgen Receptor , Drug Metabolite
T15178	DTRIM24		Others
	dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.		Others
T8864	Thymidylate Kinase Inhibitor, YMU1		Others
	YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site.		Others
T10268	AGX51		Others
			Others
T17014	TCO-NHS ester		Others , PROTAC Linker
	TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sy...		Others , PROTAC Linker

Compounds

Orlistat Degradation Product (sodium salt)

T35788

Synonym:

Target:

PROTAC TYK2 degradation agent1

T75026

Synonym:

Target: PROTACs

Erythromycin A enol ether

Target: Wnt/beta-catenin

Bis(p-chlorophenyl)acetic acid

T20933

Synonym: Bis(p-chlorphenyl)essigsaeure,Bis(4-chlorophenyl)acetic acid,DDA (degradation product),DDA

Target: Epigenetic Reader Domain

Target: Others, IGF-1R

L-006235

T21616

Synonym: L 006235

Target: Cysteine Protease

Tenovin-1

T1919

Synonym: Tenovin 1

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

Tenovin-6

T1818

Synonym: Tenovin 6

Target: Dehydrogenase, Sirtuin, Autophagy

Lenalidomide hemihydrate

T22922

Synonym:

Target: TNF, Ligand for E3 Ligase, Molecular Glues

BRD32048

T23820

Synonym: BRD-32048,BRD 32048

Target: DNA/RNA Synthesis

Amcenestrant

T12832

Synonym: SAR439859

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Tenovin-6 Hydrochloride

T8480

Synonym:

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

Synonym: Obatoclax,GX15-070

Target: BCL, Parasite, Autophagy

Lenalidomide

T1642

Synonym: CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

dCeMM3

T9758

Synonym: 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

Xevinapant

T6763

Synonym: ARRY-334543,SM-406,AT406,Debio-1143

Target: IAP

VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

T7944

Synonym: PIK-III analogue

Target: PI3K

Valproic acid sodium salt

T1602

Synonym: Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Divalproex Sodium

T6474

Synonym: Valproate semisodium,Epival

Target: HDAC

Xevinapant hydrochloride

T3299

Synonym: AT-406 HCl,SM-406

Target: Apoptosis, IAP

Target: Epigenetic Reader Domain, Ligand for E3 Ligase

Target: Mdm2, E1/E2/E3 Enzyme, IAP

Tadalafil

T1398

Synonym: Cialis,IC-351

Target: Apoptosis, PDE

PROTAC BRAF-V600E degrader-1

Target: Others, E1/E2/E3 Enzyme

Orange I

T30663

Synonym: Orange I, sodium salt,Tertracid Orange I,α-Naphthol Orange,C.I. Acid Orange 20

Target: Opioid Receptor

Pomalidomide-PEG2-OH

T9383

Synonym: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-

Target: Influenza Virus

Pomalidomide-PEG3-OH

T9384

Synonym: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]-

Synonym: p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene

Target: Androgen Receptor, Drug Metabolite

Thymidylate Kinase Inhibitor, YMU1

Target: Others, PROTAC Linker

カタログ番号	製品名	別名	ターゲット
T4940	3-Methylhistamine dihydrochloride		Others , Endogenous Metabolite
	N tau-methylhistamine is one of the histamine metabolites. N tau-methylhistamine in plasma and urine is a good parameter for histamine release, and the determination of this histamine metabolite is generally less hampere...		Others , Endogenous Metabolite
T4970	LANOSTEROL	3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.		Endogenous Metabolite
T7064	Valproic Acid	Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid	Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
T4S2157	Campesterol	(24R)-5-Ergosten-3β-ol	Endogenous Metabolite
	Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e...		Endogenous Metabolite
TN7086	Propiosyringone		Others
	Propiosyringone is from the degradation of Eucalyptus globulus wood by wood-rotting fungi.		Others
T4789	1-Hydroxy-2-naphthoic acid	ALPHA-HYDROXYNAPHTHOIC ACID	Others , Endogenous Metabolite
	1-Hydroxy-2-naphthoic acid (ALPHA-HYDROXYNAPHTHOIC ACID) is a Metabolite from phenanthrene degradation.		Others , Endogenous Metabolite
T5551	Levulinic acid	β-Acetylpropionic acid,4-Oxovaleric acid,Laevulinic acid	Others , Endogenous Metabolite
	Levulinic acid (4-Oxovaleric acid), derived from the degradation of cellulose, is a precursor for the synthesis of biofuels, such as ethyl levulinate.		Others , Endogenous Metabolite
T4887	3-Amino-2-methylpropanoic acid	DL-3-AMINOISOBUTYRIC ACID,α-Methyl-β-alanine	Endogenous Metabolite
	3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) is the product from the conversion of N-carbamyl-beta-aminoisobutyric acid by the enzyme Beta-ureidopropionase (EC 3.5.1.6), the last step in pyrimidine degradation. Be...		Endogenous Metabolite
T5248	(R)-3-Hydroxybutanoic acid		Others , Endogenous Metabolite
	3-hydroxybutyric acid is involved in the synthesis and degradation of ketone bodies. Like the other ketone bodies (acetoacetate and acetone), levels of beta-hydroxybutyrate are raised in the blood and urine in ketosis. B...		Others , Endogenous Metabolite
T8244	Raspberry ketone glucoside		Others
	Raspberry ketone glucoside is a natural product in raspberry fruit, has lasting effects for the inhibition of melanogenesis and various melanogenic factors after the degradation in the skin.		Others
TQ0214	Dimethylcurcumin	ASC-J9,GO-Y025	Androgen Receptor
	Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.		Androgen Receptor
T8165	Erythrodiol		Endogenous Metabolite , ABC
	Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.		Endogenous Metabolite , ABC
T4456	N4-Acetylcytidine	N-Acetylcytidine	Others , Endogenous Metabolite
	N4-Acetylcytidine (N-Acetylcytidine) is a modified nucleoside. N4-acetylcytidine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological mark...		Others , Endogenous Metabolite
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	PARP , Endogenous Metabolite
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).		PARP , Endogenous Metabolite
TN1833	Karacoline		NF-κB
	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.		NF-κB
T2S1840	Rebaudioside D		Others
	Rebaudioside D is a potential sweetener. Rebaudioside D shows similar stability when exposed to simulate stomach and small intestine fluids, with susceptibility to hydrolytic degradation by enteric bacteria collected fro...		Others
T3384	Wedelolactone	IKK Inhibitor II	Apoptosis , NF-κB , Lipoxygenase , Caspase
	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.		Apoptosis , NF-κB , Lipoxygenase , Caspase
T7548	1-Methylguanosine	N1-Methylguanosine	Endogenous Metabolite
	1-Methylguanosine (N1-Methylguanosine) is a methylated nucleoside. It is known that some modified, especially methylated, nucleosides originating from RNA degradation are excreted in abnormal levels in the urine of patie...		Endogenous Metabolite
T2857	2,5-Dihydroxybenzoic acid	5-Hydroxysalicylic acid,Gentisic acid,Phloretate,Carboxyhydroquinone,Hydroquinonecarboxylic acid,Gentianic acid	FGFR , Others , Endogenous Metabolite
	2,5-Dihydroxybenzoic acid (Gentisic acid) is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity, such as anti-inflammatory, antirheumatic and antioxidant properties.		FGFR , Others , Endogenous Metabolite
TN1892	Lusianthridin		Others , c-Myc
	Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signali...		Others , c-Myc
T2723	Ketoisophorone	4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione	Others
	Ketoisophorone (2,6,6-Trimethyl-2-cyclohexene-1,4-dione) is the major ingredients of saffron spice. It is a cyclic olefin and was reported as a product of the thermal degradation of β-carotene in aqueous suspension.		Others
T3914	Saikosaponin C		Beta Amyloid , Caspase
	Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.		Beta Amyloid , Caspase
TN1828	Kahweol		Apoptosis , NF-κB , AMPK
	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.		Apoptosis , NF-κB , AMPK
T3391	Corosolic acid	Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid	FAK , Autophagy
	Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci...		FAK , Autophagy
T0627	β-Alanine	beta-Alanine,3-Aminopropanoic acid,2-Carboxyethylamine	GABA Receptor , Endogenous Metabolite
	β-Alanine (3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.		GABA Receptor , Endogenous Metabolite
T3816	Velutin		NF-κB , HIF/HIF Prolyl-Hydroxylase
	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...		NF-κB , HIF/HIF Prolyl-Hydroxylase
T0983	Penicillamine	d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine	Antibiotic
	Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a...		Antibiotic
TN1805	Isosilybin B		Apoptosis , Androgen Receptor
	Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes to G1-phase blockade and apoptosis.Isosilybin B induces degr...		Apoptosis , Androgen Receptor
T5060	2-Oxobutanoic acid	alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid	Others , Endogenous Metabolite
	2-Oxobutanoic acid (alpha-Ketobutyric Acid) is a product of the lysis of cystathionine. It is also one of the degradation products of threonine. It can be converted into propionyl-CoA, and thus enter the citric acid cycl...		Others , Endogenous Metabolite
TN1677	Gartanin		BCL , Caspase , JNK
	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...		BCL , Caspase , JNK
TJS0856	Dalbergin	6-Hydroxy-7-Methoxy-4-Phenylcoumarin	Others
	1. Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) exhibits similar bone conserving effect against bone-loss as estradiol treatment, it as a therapeutic candidate against postmenopausal osteoporosis. 2. Dalbergin preven...		Others
T19124	3-Oxocholic acid	3-Ketocholic acid	Endogenous Metabolite
	3-Oxocholic acid(3-Ketocholic acid) is the metabolite of bile acid and the main product of bile degradation by Clostridium perfringens in the intestine.3-Oxocholic acid is a steroid acid mainly found in the bile of mamma...		Endogenous Metabolite
T4237	Rubiadin-1-methyl ether	Rubiadin 1-methyl ether	Anti-infection , NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu...		Anti-infection , NF-κB
T5216	Calcium L-Threonate	L-Threonic acid Calcium Salt	Others , Endogenous Metabolite
	Calcium L-Threonate (L-Threonic acid Calcium Saltr) is probably derived from glycated proteins or from the degradation of ascorbic acid. Calcium L-Threonate is a normal component is aqeous humour and blood. Calcium L-Thr...		Others , Endogenous Metabolite
T6S1780	Protosappanin B	Q-100961,FT-0689654	Apoptosis
	1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi...		Apoptosis
T6599	N6-methyladenosine	N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A	Others , Influenza Virus , Endogenous Metabolite
	N6-methyladenosine (NSC-29409) is a methylated adenine residue. N6-Methyladenosine is an endogenous urinary nucleoside product of the degradation of transfer ribonucleic acid (tRNA); urinary nucleosides are biological ma...		Others , Influenza Virus , Endogenous Metabolite
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
TL0001	Dencichine	L-Dencichin,ODAP,Dencichin	Others , HIF/HIF Prolyl-Hydroxylase
	Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...		Others , HIF/HIF Prolyl-Hydroxylase
T0665	Xanthine	2,6-Dihydroxypurine,Isoxanthine	Endogenous Metabolite , Adenosine Receptor
	Xanthine (Isoxanthine) is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most body tissues and fluids in...		Endogenous Metabolite , Adenosine Receptor
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T5236	N-Methylhydantoin	Dioxy-creatinine,1-Methyl-hydantoin	Others , Endogenous Metabolite
	N-Methylhydantoin (1-Methyl-hydantoin) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. In mammals, the Metabolism of N-Methylhydantoin occurs via 5-hydroxy-1-methylhydan...		Others , Endogenous Metabolite
T5253	3-Methyladipic acid		Others , Endogenous Metabolite
	3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation, and so the w-oxidation pathway is the only metabo...		Others , Endogenous Metabolite
T10619	Bromelain		Apoptosis , Others
	Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,...		Apoptosis , Others
T5280	3-Chloro-L-Tyrosine	3-Chlorotyrosine,Chlorotyrosine	Others , Endogenous Metabolite
	3-Chloro-L-Tyrosine (Chlorotyrosine), a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. In particular, myeloperoxidase h...		Others , Endogenous Metabolite
TCS2070	Homogentisic acid	2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid	Antioxidant , Endogenous Metabolite
	1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant...		Antioxidant , Endogenous Metabolite
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T4705	Aminoadipic acid	DL-2-Aminoadipic acid	Others , Endogenous Metabolite
	Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine...		Others , Endogenous Metabolite
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
T4799	Indole		Others , Endogenous Metabolite
	Indole has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. ...		Others , Endogenous Metabolite
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天然物製品

3-Methylhistamine dihydrochloride

T4940

Synonym:

Target: Others, Endogenous Metabolite

LANOSTEROL

T4970

Synonym: 3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Valproic Acid

T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

Campesterol

T4S2157

Synonym: (24R)-5-Ergosten-3β-ol

Target: Endogenous Metabolite

1-Hydroxy-2-naphthoic acid

T4789

Synonym: ALPHA-HYDROXYNAPHTHOIC ACID

Target: Others, Endogenous Metabolite

Levulinic acid

T5551

Synonym: β-Acetylpropionic acid,4-Oxovaleric acid,Laevulinic acid

Target: Others, Endogenous Metabolite

3-Amino-2-methylpropanoic acid

T4887

Synonym: DL-3-AMINOISOBUTYRIC ACID,α-Methyl-β-alanine

Target: Endogenous Metabolite

(R)-3-Hydroxybutanoic acid

T5248

Synonym:

Target: Others, Endogenous Metabolite

Raspberry ketone glucoside

Synonym: ASC-J9,GO-Y025

Target: Androgen Receptor

Erythrodiol

T8165

Synonym:

Target: Endogenous Metabolite, ABC

N4-Acetylcytidine

T4456

Synonym: N-Acetylcytidine

Target: Others, Endogenous Metabolite

Nudifloramide

T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Target: PARP, Endogenous Metabolite

Synonym: IKK Inhibitor II

Target: Apoptosis, NF-κB, Lipoxygenase, Caspase

1-Methylguanosine

T7548

Synonym: N1-Methylguanosine

Target: Endogenous Metabolite

2,5-Dihydroxybenzoic acid

T2857

Synonym: 5-Hydroxysalicylic acid,Gentisic acid,Phloretate,Carboxyhydroquinone,Hydroquinonecarboxylic acid,Gentianic acid

Target: FGFR, Others, Endogenous Metabolite

Lusianthridin

TN1892

Synonym:

Target: Others, c-Myc

Ketoisophorone

T2723

Synonym: 4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione

Target: Beta Amyloid, Caspase

Kahweol

TN1828

Synonym:

Target: Apoptosis, NF-κB, AMPK

Corosolic acid

T3391

Synonym: Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid

Target: FAK, Autophagy

β-Alanine

T0627

Synonym: beta-Alanine,3-Aminopropanoic acid,2-Carboxyethylamine

Target: GABA Receptor, Endogenous Metabolite

Velutin

T3816

Synonym:

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

Penicillamine

T0983

Synonym: d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine

Target: Apoptosis, Androgen Receptor

2-Oxobutanoic acid

T5060

Synonym: alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid

Target: Others, Endogenous Metabolite

Gartanin

TN1677

Synonym:

Target: BCL, Caspase, JNK

Dalbergin

TJS0856

Synonym: 6-Hydroxy-7-Methoxy-4-Phenylcoumarin

Target: Others

3-Oxocholic acid

T19124

Synonym: 3-Ketocholic acid

Target: Endogenous Metabolite

Rubiadin-1-methyl ether

T4237

Synonym: Rubiadin 1-methyl ether

Target: Anti-infection, NF-κB

Calcium L-Threonate

T5216

Synonym: L-Threonic acid Calcium Salt

Target: Others, Endogenous Metabolite

Protosappanin B

T6S1780

Synonym: Q-100961,FT-0689654

Target: Apoptosis

N6-methyladenosine

T6599

Synonym: N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A

Target: Others, Influenza Virus, Endogenous Metabolite

Eurycomalactone

TN1637

Synonym:

Target: Anti-infection, NF-κB

dencichine

TL0001

Synonym: L-Dencichin,ODAP,Dencichin

Target: Others, HIF/HIF Prolyl-Hydroxylase

Xanthine

T0665

Synonym: 2,6-Dihydroxypurine,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

Steviol

T2S1837

Synonym: NSC 226902,Hydroxydehydrostevic acid

Target: Others

N-Methylhydantoin

T5236

Synonym: Dioxy-creatinine,1-Methyl-hydantoin

Target: Others, Endogenous Metabolite

3-Methyladipic acid

T5253

Synonym:

Target: Others, Endogenous Metabolite

Bromelain

T10619

Synonym:

Target: Apoptosis, Others

3-Chloro-L-Tyrosine

T5280

Synonym: 3-Chlorotyrosine,Chlorotyrosine

Target: Others, Endogenous Metabolite

Homogentisic acid

TCS2070

Synonym: 2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid

Target: Antioxidant, Endogenous Metabolite

Platycodin D

T3889

Synonym:

Target: Prostaglandin Receptor, AMPK

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Aminoadipic acid

T4705

Synonym: DL-2-Aminoadipic acid

Target: Others, Endogenous Metabolite

Urolithin B

T13265

Synonym:

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Indole

T4799

Synonym:

Target: Others, Endogenous Metabolite

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03390	LSM1 Protein, Human, Recombinant (His)	Human	E. coli
	LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions ...
TMPY-03870	EDEM2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and ...
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPY-00541	LON PROTEASE Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura...
TMPY-02078	HtrA2/Omi Protein, Human, Recombinant (His)	Human	E. coli
	Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the ...
TMPY-00828	Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfat...
TMPJ-01386	STUB1 Protein, Human, Recombinant	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPH-03455	Polyphosphatase/PPX1 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	E. coli
	Degradation of inorganic polyphosphates.
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
TMPH-03613	NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)	Synechococcus elongatus	E. coli
	Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechoco...
TMPH-02432	Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)	Cynomolgus	E. coli
	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Requir...
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...
TMPH-02431	Legumain Protein, Cynomolgus, Recombinant (His & Myc)	Cynomolgus	Baculovirus Insect Cells
	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Requir...
TMPH-02149	ALDH5A1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
TMPH-03282	TRIM63 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein...
TMPH-02634	TRIM63 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein...
TMPH-01271	TRIM63 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein...
TMPJ-00823	UBB Protein, Human, Recombinant	Human	E. coli
	Polyubiquitin-B(UBB) is one of Ubiquitins. Ubiquitin is one of the most conserved proteins known in eukaryotic organisms. Ubiquitin is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnorm...
TMPH-01269	SMURF2 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPH-00520	Host-nuclease inhibitor protein gam Protein, Enterobacteria phage lambda, Recombinant (His & Myc)	Escherichia phage lambda	E. coli
	Binds to host RecBCD nuclease and inhibits it thereby protecting the viral DNA against recBCD mediated degradation.
TMPH-02641	ECEL1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Nega...
TMPJ-01035	UBE2G2 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPH-02847	CNPY2 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
TMPH-00869	ADAMTS7 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.1 kDa and the accession number is Q9...
TMPH-00582	Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPH-00209	CLPP2 Protein, Borrelia burgdorferi, Recombinant (His & Myc)	Borrelia burgdorferi	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPH-02594	MMP-13 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the hig...
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPH-00868	ADAMTS7 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.1 kD...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool...
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His)	HIV-2	P. pastoris (Yeast)
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-01063	Cathepsin O Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predic...
TMPJ-01249	ASB13 Protein, Human, Recombinant (His)	Human	E. coli
	Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppre...
TMPH-00685	Exopolyphosphatase Protein, E. coli O6:H1, Recombinant (His)	E. coli	E. coli
	Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Exopolyphosphatase Protein, E. coli O6:H1, Recombinant (His) is expressed in E. coli expression syst...
TMPH-01062	Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag...
TMPH-01650	PRAME Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination a...
TMPJ-00938	4HPPD Protein, Human, Recombinant (His)	Human	E. coli
	4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydro...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPH-00618	Exopolyphosphatase Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has a strong preference for long-chain polyphosphates and has only weak affinity for smaller size po...
TMPH-00581	ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His) is expressed in E. coli expressio...
TMPH-02581	Chymase 1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Chymase 1 Protein, Mouse, Recombinant (His) is expressed i...
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and ...
TMPH-03401	Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expressi...
TMPH-01060	Cathepsin F Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Cathepsin F Protein, Human, Recombinant (His) is expressed...
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LSM1 Protein, Human, Recombinant (His)

TMPY-03390

Species: Human

Expression System: E. coli

EDEM2 Protein, Human, Recombinant (His)

TMPY-03870

Species: Human

Expression System: HEK293 Cells

IL-17 Protein, Mouse, Recombinant (His)

TMPJ-01172

Species: Mouse

Expression System: HEK293 Cells

LON PROTEASE Protein, E. coli, Recombinant (His)

TMPY-00541

Species: E. coli

Expression System: E. coli

HtrA2/Omi Protein, Human, Recombinant (His)

TMPY-02078

Species: Human

Expression System: E. coli

Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)

TMPY-00828

Species: Human

Expression System: HEK293 Cells

STUB1 Protein, Human, Recombinant

TMPJ-01386

Species: Human

Expression System: E. coli

Polyphosphatase/PPX1 Protein, S. cerevisiae, Recombinant (His)

TMPH-03455

Species: Saccharomyces cerevisiae

Expression System: E. coli

Properdin Protein, Mouse, Recombinant (His & Myc)

TMPH-02845

Species: Mouse

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His)

TMPH-02844

Species: Mouse

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

TMPH-01273

Species: Human

Expression System: E. coli

NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)

TMPH-03613

Species: Synechococcus elongatus

Expression System: E. coli

Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)

TMPH-02432

Species: Cynomolgus

Expression System: E. coli

AMFR Protein, Human, Recombinant (His)

TMPH-01259

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

TMPH-01260

Species: Human

Expression System: HEK293 Cells

SKP2 Protein, Human, Recombinant (His & SUMO)

TMPH-02131

Species: Human

Expression System: E. coli

Legumain Protein, Cynomolgus, Recombinant (His & Myc)

TMPH-02431

Species: Cynomolgus

Expression System: Baculovirus Insect Cells

ALDH5A1 Protein, Human, Recombinant (His)

TMPH-02149

Species: Human

Expression System: P. pastoris (Yeast)

TRIM63 Protein, Rat, Recombinant (His & Myc)

TMPH-03282

Species: Rat

Expression System: E. coli

TRIM63 Protein, Mouse, Recombinant (His & Myc)

TMPH-02634

Species: Mouse

Expression System: E. coli

TRIM63 Protein, Human, Recombinant (His & Myc)

TMPH-01271

Species: Human

Expression System: E. coli

UBB Protein, Human, Recombinant

TMPJ-00823

Species: Human

Expression System: E. coli

SMURF2 Protein, Human, Recombinant (His)

TMPH-01269

Species: Human

Expression System: E. coli

Host-nuclease inhibitor protein gam Protein, Enterobacteria phage lambda, Recombinant (His & Myc)

TMPH-00520

Species: Escherichia phage lambda

Expression System: E. coli

ECEL1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02641

Species: Mouse

Expression System: E. coli

SPSB1 Protein, Human, Recombinant (His)

TMPH-02136

Species: Human

Expression System: E. coli

UBE2G2 Protein, Human, Recombinant (GST)

TMPJ-01035

Species: Human

Expression System: E. coli

CNPY2 Protein, Mouse, Recombinant (His & Myc)

TMPH-02847

Species: Mouse

Expression System: E. coli

ADAMTS7 Protein, Human, Recombinant (His)

TMPH-00869

Species: Human

Expression System: P. pastoris (Yeast)

Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)

TMPH-00582

Species: E. coli

Expression System: E. coli

CLPP2 Protein, Borrelia burgdorferi, Recombinant (His & Myc)

TMPH-00209

Species: Borrelia burgdorferi

Expression System: E. coli

MMP-13 Protein, Mouse, Recombinant (His)

TMPH-02594

Species: Mouse

Expression System: E. coli

WWP2 Protein, Human, Recombinant (His & GST)

TMPY-02950

Species: Human

Expression System: Baculovirus Insect Cells

ADAMTS7 Protein, Human, Recombinant (His & SUMO)

TMPH-00868

Species: Human

Expression System: E. coli

EGLN1 Protein, Human, Recombinant (His & Myc)

TMPH-01280

Species: Human

Expression System: E. coli

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

TMPH-03415

Species: RVFV

Expression System: E. coli

HIV-2 (subtype A, isolate ROD) Protein Vpx (His)

TMPH-01522

Species: HIV-2

Expression System: P. pastoris (Yeast)

Cathepsin O Protein, Human, Recombinant (His & Myc)

TMPH-01063

Species: Human

Expression System: HEK293 Cells

ASB13 Protein, Human, Recombinant (His)

TMPJ-01249

Species: Human

Expression System: E. coli

Exopolyphosphatase Protein, E. coli O6:H1, Recombinant (His)

TMPH-00685

Species: E. coli

Expression System: E. coli

Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01062

Species: Human

Expression System: E. coli

PRAME Protein, Human, Recombinant (E. coli, His)

TMPH-01650

Species: Human

Expression System: E. coli

4HPPD Protein, Human, Recombinant (His)

TMPJ-00938

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

TMPH-02282

Species: Human

Expression System: E. coli

Exopolyphosphatase Protein, E. coli, Recombinant (His & SUMO)

TMPH-00618

Species: E. coli

Expression System: E. coli

ATP-dependent Clp protease adapter protein ClpS Protein, E. coli, Recombinant (His)

TMPH-00581

Species: E. coli

Expression System: E. coli

Chymase 1 Protein, Mouse, Recombinant (His)

TMPH-02581

Species: Mouse

Expression System: E. coli

Fbxo3 Protein, Mouse, Recombinant (His & Myc)

TMPH-02651

Species: Mouse

Expression System: E. coli

Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc)

TMPH-03401

Species: Rat

Expression System: E. coli

Cathepsin F Protein, Human, Recombinant (His)

TMPH-01060

Species: Human

Expression System: E. coli

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	A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening；
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	555 glycolysis-related active compounds for high-throughput and high-content screening.
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