Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP .
説明 | YHO-13351 free base is the water-soluble prodrug of YHO-13177 which is an inhibitor of BCRP . |
In vivo | In mice, YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of Irinotecan Hydrochloride with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas Irinotecan Hydrochloride alone had little effect in these tumor models[1]. |
分子量 | 483.62 |
分子式 | C26H33N3O4S |
CAS No. | 912288-64-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (186.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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YHO-13351 free base 912288-64-3 Membrane transporter/Ion channel BCRP YHO-13351 YHO 13351 free base YHO13351 YHO 13351 YHO13351 free base Inhibitor inhibitor inhibit