Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
説明 | PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. |
ターゲット&IC50 | BTK:8.2 nM |
In vitro | PCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the 'gatekeeper” residue. In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition. |
別名 | PCI29732, PCI-29732 |
分子量 | 371.43 |
分子式 | C22H21N5O |
CAS No. | 330786-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: >53 mg/mL
You can also refer to dose conversion for different animals. 詳細
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PCI 29732 330786-25-9 Angiogenesis Membrane transporter/Ion channel Others Tyrosine Kinase/Adaptors BCRP BTK cytotoxicity PCI29732 Bruton tyrosine kinase Inhibitor Btk ABCG2 reversible BCR inhibit PCI-29732 B-cell oral Breast cancer resistance protein inhibitor