Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 67,500 |
5 mg | 在庫あり | ¥ 143,000 |
10 mg | 在庫あり | ¥ 225,500 |
25 mg | 在庫あり | ¥ 335,000 |
50 mg | 在庫あり | ¥ 452,500 |
100 mg | 在庫あり | ¥ 608,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 164,000 |
説明 | YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM). |
ターゲット&IC50 | SCD:30.4 μM, Ole1:39 nM |
In vitro | YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1]. |
分子量 | 458.51 |
分子式 | C25H26N6O3 |
CAS No. | 2225824-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.05 mM)
You can also refer to dose conversion for different animals. 詳細
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YTX-465 2225824-53-1 Metabolism Stearoyl-CoA Desaturase (SCD) α-synuclein fatty desaturation YTX 465 Inhibitor Parkinson’s disease YTX465 inhibit synucleinopathies inhibitor