Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.
説明 | Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. |
In vivo | Z944 dose dependently (1, 3, 10mg/kg; i.p.) altered CMOR memory in GAERS compared to the non-epileptic control (NEC) strain. GAERS demonstrated recognition memory deficits in the visual and crossmodal variations of the CMOR task that were reversed by the highest dose of Z944. Electroencephalogram recordings determined that deficits in CMOR memory in GAERS were not the result of seizures during task performance. In contrast, NEC showed a decrease in CMOR memory following Z944 treatment[2]. |
別名 | Z 944, Z-944 |
分子量 | 383.89 |
分子式 | C19H27ClFN3O2 |
CAS No. | 1199236-64-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13 mg/ml (33.86 mM)
You can also refer to dose conversion for different animals. 詳細
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Z944 1199236-64-0 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels Inhibitor Z 944 Ca2+ channels Z-944 inhibit inhibitor