Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 24,500 | |||
5 mg | 在庫あり | ¥ 52,500 | |||
10 mg | 在庫あり | ¥ 98,500 | |||
25 mg | 在庫あり | ¥ 164,500 | |||
50 mg | 在庫あり | ¥ 226,500 | |||
100 mg | 在庫あり | ¥ 314,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 58,000 |
説明 | Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). |
ターゲット&IC50 | PDE4D7:7.8 nM, PDE4D3:7.4 nM |
In vivo | BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus [1]. BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3 mg/kg [2]. |
別名 | BPN14770 |
分子量 | 405.8 |
分子式 | C21H15ClF3NO2 |
CAS No. | 1606974-33-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (640.71 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Zatolmilast 1606974-33-7 Metabolism Others PDE Phosphodiesterase (PDE) Inhibitor BPN14770 BPN-14770 BPN 14770 inhibit inhibitor