store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMI-1 free acid is a cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs) with potential anticancer activity, inhibits PRMT1 and yeast Hmt1p, inhibits arginine methylation, and modulates nuclear receptor-regulated transcription from estrogen- and androgen-responsive elements.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 9,500 | |||
50 mg | 在庫あり | ¥ 13,000 | |||
100 mg | 在庫あり | ¥ 18,500 | |||
500 mg | 在庫あり | ¥ 45,500 | |||
1 g | 在庫あり | ¥ 67,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,000 |
説明 | AMI-1 free acid is a cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs) with potential anticancer activity, inhibits PRMT1 and yeast Hmt1p, inhibits arginine methylation, and modulates nuclear receptor-regulated transcription from estrogen- and androgen-responsive elements. |
In vitro | In S180 cells and U2OS cells, AMI-1, free acid (0.6 mM, 1.2 mM, 2.4 mM; 48 hours, 72 hours, 96 hours) inhibits cell viability[3]. |
In vivo | AMI-1, free acid (0.5 mg; administered daily via subcutaneous injection for 7 days) reduces tumor weight in male Kunming mice with S180 cell xenografts[3]. |
分子量 | 504.49 |
分子式 | C21H16N2O9S2 |
CAS No. | 134-47-4 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (118.93 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AMI-1 free acid 134-47-4 Chromatin/Epigenetic Histone Methyltransferase AMI 1, free acid AMI-1, free acid AMI1, free acid Inhibitor inhibitor inhibit