store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
説明 | LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. |
ターゲット&IC50 | PRMT5:(ki)6 nM, PRMT5:22 nM, MEP50:(ki)6 nM, MEP50:22 nM |
In vitro | LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM[1]. |
In vivo | LLY-283 administered orally at a dose of 20 mg/kg daily significantly inhibits tumor growth in A375 cell-bearing mice over a 28-day treatment period[1]. |
分子量 | 342.35 |
分子式 | C17H18N4O4 |
CAS No. | 2040291-27-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 3.57 mg/mL (10.43 mM), Sonication and heating to 60℃ are recommended.
DMSO: 112.5 mg/mL (328.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LLY-283 2040291-27-6 Chromatin/Epigenetic Histone Methyltransferase LLY283 LLY 283 Inhibitor inhibitor inhibit