Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosphorylation within the PI3K/Akt signaling pathway to exert its effects and suppresses cell proliferation through the inhibition of the MEK/ERK signaling pathway in colorectal cancer [1] [2].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid leukemia (CML) cell line K562. It diminishes protein phosphorylation within the PI3K/Akt signaling pathway to exert its effects and suppresses cell proliferation through the inhibition of the MEK/ERK signaling pathway in colorectal cancer [1] [2]. |
In vitro | CML-IN-1 (compound 7) exhibited the least cytotoxicity and enhanced bioactivity in cellular assays (K562, IC50: 0.038 µM) [1]. CML-IN-1 (compound 4) significantly inhibited the proliferation of HCT116 cells with IC50 values of 8.04 ± 0.94 µM at 48 hours and 5.52 ± 0.42 µM at 72 hours [2]. Additionally, CML-IN-1 (compound 4) suppressed colony formation, migration, and invasion of HCT116 cells in a dose-dependent manner, induced apoptosis, and caused cell cycle arrest at the G2/M phase [2]. It also inhibited the activation of MEK/ERK signaling pathways in HCT116 cells [2]. |
分子量 | 540.58 |
分子式 | C21H23F3N8O2S2 |
CAS No. | 2235393-30-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Anticancer agent 164 2235393-30-1 Apoptosis Inhibitor inhibitor inhibit