Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the antibody-agent conjugate (ADC) T-PBA. T-PBA retains the targeting and internalization properties of Trastuzumab [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | お問い合わせ | ¥ 429,500 |
50 mg | お問い合わせ | ¥ 867,500 |
100 mg | お問い合わせ | ¥ 1,193,500 |
説明 | Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the antibody-agent conjugate (ADC) T-PBA. T-PBA retains the targeting and internalization properties of Trastuzumab [1]. |
In vitro | Anticancer agent 81 (Compound 37b3) demonstrates cytotoxic effects on SKOV3, MDA-MB-231, and NCI-N87 cells after 72 hours of exposure [1]. It induces DNA interstrand cross-linking at concentrations ranging from 0 to 5 µM [1] and causes S-phase cell cycle arrest in SKOV3 cells at 0-3 nM concentrations over 24 hours, leading to apoptosis after 48 hours [1]. At a 25 nM dosage for 12 hours, this compound penetrates the nuclei of SKOV3 and MDA-MB-231 cells, targeting DNA [1]. Furthermore, Anticancer agent 81 triggers DDR signaling pathways through DNA cross-linking, subsequently activating the caspase cascade and PARP, which results in cell cycle arrest and apoptosis [1]. The compound also forms covalent bonds with DNA sequences, predominantly interacting with the major groove of DNA [1]. |
In vivo | Administered intravenously at doses of 1-10 mg/kg every three days for a total of four doses, T-PBA markedly inhibited tumor progression in two Her2-positive mouse xenograft models, demonstrating superior efficacy to Trastuzumab [1] with no apparent toxicity or adverse effects. |
分子量 | 762.89 |
分子式 | C46H46N6O5 |
CAS No. | 2820286-56-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Anticancer agent 81 2820286-56-2 Apoptosis Inhibitor inhibitor inhibit