Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6/AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates anti-tumor activity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 418,000 |
50 mg | 約8-10 週間 | ¥ 546,500 |
100 mg | 約8-10 週間 | ¥ 711,500 |
説明 | AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6/AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates anti-tumor activity [1]. |
In vitro | AXL-IN-14, at concentrations of 0.2, 1, and 5 nM for 1 hour, demonstrated a dose-dependent decrease in the expression levels of p-AXL and p-AKT proteins [1]. With a 72-hour exposure, AXL-IN-14 exhibited antiproliferative activity, achieving an IC50 value of 21.8 nM in EBC-1 cells [1]. Additionally, AXL-IN-14, at 20 and 100 nM for 24 hours, inhibited Gas6/AXL-mediated cell migration and invasion in H1299 and SNU449 cells [1]. |
In vivo | AXL-IN-14 (1, 10 mg/kg; p.o.; once daily for 11 days) demonstrated antitumor activity in nude mice [1]. |
分子量 | 566.55 |
分子式 | C32H24F2N4O4 |
CAS No. | 2947506-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AXL-IN-14 2947506-65-0 Tyrosine Kinase/Adaptors TAM Receptor Inhibitor inhibitor inhibit