Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 41,500 | |||
5 mg | 在庫あり | ¥ 96,000 | |||
10 mg | 在庫あり | ¥ 142,000 | |||
25 mg | 在庫あり | ¥ 227,000 | |||
50 mg | 在庫あり | ¥ 305,500 | |||
100 mg | 在庫あり | ¥ 408,500 | |||
500 mg | 在庫あり | ¥ 822,000 |
説明 | BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit. |
In vitro | BMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 [1]. Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement [2]. In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA [3]. |
In vivo | BMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis [4]. Oral administration of BMS 195614 did not suppress spermatogenesis in mice [5]. |
別名 | BMS614 |
分子量 | 448.51 |
分子式 | C29H24N2O3 |
CAS No. | 253310-42-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.1 mg/mL (22.5 mM)
You can also refer to dose conversion for different animals. 詳細
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BMS 195614 253310-42-8 Metabolism Retinoid Receptor BMS-614 BMS195614 BMS 614 BMS614 BMS-195614 Inhibitor inhibitor inhibit