Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 tumor cells in nude mice[1].
説明 | BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 tumor cells in nude mice[1]. |
In vitro | BX-2819 (0.001-10 nM , 16 h) inhibits the expression of ErbB2 protein and significantly enhances the expression of Hsp70 in HT-29, OVCAR3, and SKBR3 cells [1]. |
In vivo | BX-2819 administered at 100 mg/kg intraperitoneally (i.p.) twice weekly substantially inhibited the expression of ErbB2 protein in NCI-N87 and SKOV3 tumor-bearing mice. Additionally, in HT-29 and NCI-N87 tumor models, it significantly reduced tumor growth and overall tumor burden [1]. A single dose of BX-2819 at 2 mg/kg given intravenously (i.v.) demonstrated a relatively short serum half-life (t1/2 = 0.8 h), high clearance (CL = 159 mL/min/kg), and a large volume of distribution (Vss = 4.5 L) in mice [1]. |
分子量 | 428.51 |
分子式 | C21H24N4O4S |
CAS No. | 1184181-50-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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BX-2819 1184181-50-7 Cytoskeletal Signaling Metabolism HSP Inhibitor inhibitor inhibit