Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
説明 | HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors. |
In vitro | HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells[1]. |
In vivo | HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors[1]. |
分子量 | 466.58 |
分子式 | C23H22N4O3S2 |
CAS No. | 1609402-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 86 mg/mL (184.3 mM)
Ethanol: 42 mg/mL (90 mM)
You can also refer to dose conversion for different animals. 詳細
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HA15 1609402-14-3 Apoptosis Autophagy Cytoskeletal Signaling Endocrinology/Hormones GPCR/G Protein Metabolism Others HSP GPR HA-15 Inhibitor HA 15 inhibit Heat shock proteins inhibitor