Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 but also prevents the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, which consequently inhibits breast cancer cell migration [1].
説明 | PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 but also prevents the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, which consequently inhibits breast cancer cell migration [1]. |
分子量 | 1277.71 |
分子式 | C72H100N12O7S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CARM1 degrader-2 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibitor inhibit