Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 54,500 | |||
10 mg | 在庫あり | ¥ 96,000 | |||
25 mg | 在庫あり | ¥ 160,000 | |||
50 mg | 在庫あり | ¥ 228,000 | |||
100 mg | 在庫あり | ¥ 305,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 68,000 |
説明 | MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
ターゲット&IC50 | Menin:6.5 nM(Kd), Menin-MLL:21 nM |
In vitro | Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression. |
In vivo | Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight. |
分子量 | 566.6 |
分子式 | C27H25F3N8OS |
CAS No. | 1857417-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (167.67 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MI-538 1857417-10-7 Chromatin/Epigenetic Epigenetic Reader Domain Histone Methyltransferase inhibit Inhibitor MI538 MI 538 inhibitor